RED CELLS, IRON, AND ERYTHROPOIESIS Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin
نویسندگان
چکیده
1Département Médical, Ecole Nationale de Ski et d’Alpinisme, Chamonix, France; 2Department of Human Morphology and Biomedical Sciences Città Studi, University of Milano, Milano, Italy; 3Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy; 4Department of Sciences and Biomedical Technologies, University of Milano, Segrate, Italy; 5The Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark; 6Proteomics of Iron Metabolism Unit, Department of Biotechnologies, San Raffaele Scientific Institute, Milano, Italy; 7Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; 8Laboratoire de Biochimie, Hôpital Henri-Mondor, Créteil, France; and 9Department of Sport Science, University of Århus, Århus, Denmark
منابع مشابه
Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin.
The high iron demand associated with enhanced erythropoiesis during high-altitude hypoxia leads to skeletal muscle iron mobilization and decrease in myoglobin protein levels. To investigate the effect of enhanced erythropoiesis on systemic and muscle iron metabolism under nonhypoxic conditions, 8 healthy volunteers were treated with recombinant erythropoietin (rhEpo) for 1 month. As expected, t...
متن کاملRed blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects.
Limited red blood cell (RBC) regeneration often prevents collection of sufficient blood from autologous donors. We studied the effects of subcutaneous recombinant erythropoietin (rEPO) in subjects making frequent blood donations. Six healthy iron-replete male subjects took rEPO (200 U/kg) subcutaneously daily, and donated blood (450 mL) twice a week for 3 weeks. During a control study, these su...
متن کاملThe Relationship between Thyroid Hormone Levels and Body Iron Status in Iranian Hypothyroidism Patients
Backgrounds and Aims: Thyroid hormones have a crucial physiological role to maintain balance of metabolism of body. Thyroid hormones have an important role in metabolism and proliferation of blood cells. Thyroid gland also has a vital influence on erythropoiesis by induction of erythropoietin secretion and proliferation of erythroid progenitors. In the present study, it was tried to evaluate th...
متن کاملHypoxic regulation of erythropoiesis and iron metabolism.
The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription facto...
متن کاملEffects of early human recombinant erythropoietin therapy on the transfusion in healthy preterm infants.
OBJECTIVE Early recombinant erythropoietin therapy and iron therapy would decrease the need for red blood cells transfusions and prevents anemia of prematurity. METHODS Fifty-eight preterm infants in newborn services at Ghaem Medical Center randomly were assigned, among them 18 patients were excluded. A total of 40 preterm infants with gestational age 28-34 weeks, birth weight 1000-1750 g fol...
متن کامل